SLU PP 332

**Product Desciption: SLU-PP-332 (Research Grade Receptor Agonist)** Before ordering please ensure you have researched SLU PP 332 reconstitution. This product will NOT reconstitute with BAC water. See below for details. SLU-PP-332 is a potent and selective synthetic agonist of the Estrogen-Related Receptors (ERRs), specifically targeting the ERRα, ERRβ, and ERRγ isoforms. Unlike traditional estrogen receptors, ERRs are orphan nuclear receptors that function as constitutively active transcription factors. SLU-PP-332 acts as a functional mimetic of physical exertion at the molecular level, binding to the ligand-binding domain of these receptors to enhance the expression of genes involved in mitochondrial biogenesis and oxidative metabolism. In preclinical *in vitro* models, the compound has demonstrated a remarkable ability to upregulate the PGC-1α/β signaling axis, leading to increased oxygen consumption and enhanced cellular bioenergetics without the requirement of exogenous hormonal stimulation. Research applications for SLU-PP-332 primarily focus on the investigation of metabolic homeostasis and musculoskeletal physiology. Facilitating the transition of glycolytic fibers to oxidative, slow-twitch muscle fibers in laboratory settings, this compound serves as a critical tool for studying the molecular pathways of energy expenditure and lipid oxidation. Furthermore, investigators utilize SLU-PP-332 to explore the stabilization of the mitochondrial genome and the mitigation of metabolic dysfunction in specialized cell lines. Its high degree of selectivity across the ERR subfamily allows for precise mapping of nuclear receptor signaling involved in thermogenesis and glucose utilization within controlled laboratory environments. **Handling, Reconstitution, and Storage** This product is supplied as a lyophilized powder and is intended exclusively for *in vitro* laboratory research. For optimal stabilization, it is recommended to reconstitute SLU-PP-332 using an anhydrous solvent such as DMSO or ethanol, as aqueous solubility may be limited depending on the experimental concentration required. Once reconstituted, the solution should be divided into single-use aliquots to avoid repeated freeze-thaw cycles, which can lead to peptide degradation. The lyophilized powder should be stored at -20°C for long-term stability, while reconstituted solutions should be kept at -80°C and used within a strictly defined experimental timeframe to ensure consistent pharmacological potency. **FOR RESEARCH AND LABORATORY USE ONLY. Not for human or veterinary use. This product is not intended to diagnose, treat, cure, or prevent any disease.**