Retatrutide Research Peptide UK
LY3437943 — a single-molecule triple agonist of the GIP, GLP-1 and glucagon receptors, supplied lyophilised for in-vitro laboratory research.
- Available strengths: 10mg · 20mg · 30mg · 40mg
- Dispatched from the UK with tracked delivery
- Batch tested
Fulfilled from batch LEGACY
This product is sold strictly for in-vitro research and laboratory use only. Not for human consumption, veterinary use, or therapeutic application.
Research Overview
Compound Identity
- Compound
- Retatrutide
- Development code
- LY3437943
- Class
- Synthetic 39-amino-acid peptide (GIP analogue backbone)
- Receptor targets
- GIPR · GLP-1R · GCGR (triple agonist)
- Molecular formula
- C221H342N46O68
- Molecular weight
- ≈ 4731.3 g/mol
- CAS number
- 2381089-83-2
- Form
- White lyophilised powder, sealed glass vial
- Modification
- C20 fatty diacid side chain for albumin binding
Receptor pharmacology
Retatrutide (LY3437943) is built on a GIP peptide backbone that has been engineered to also engage the GLP-1 and glucagon receptors from a single molecule. That tri-agonist profile is what distinguishes it from single-agonist compounds such as semaglutide and dual GIP/GLP-1 agonists such as tirzepatide.
Published preclinical characterisation reports balanced but non-equal potency across the three receptors, with the strongest activity at GIPR, followed by GCGR and GLP-1R. The glucagon receptor arm is the component that attracts most research attention, as GCGR signalling is associated with hepatic lipid oxidation and increased energy expenditure in animal models — pathways that GIP/GLP-1 agonism alone does not directly recruit.
- GIPR — incretin signalling and adipose tissue metabolism
- GLP-1R — glucose-dependent insulin secretion and gastric motility models
- GCGR — hepatic glucose output and lipid oxidation models
Research context
Laboratory interest in retatrutide centres on comparative receptor-signalling work: cAMP accumulation assays across transfected receptor lines, β-arrestin recruitment profiling, and rodent models of energy balance and hepatic steatosis. The C20 fatty diacid side chain drives reversible albumin binding, which extends the compound's in-vivo half-life and makes it suitable for extended-interval dosing designs in animal studies.
Because the compound engages three receptors simultaneously, experimental designs typically include selective receptor antagonists or knockout lines so that the contribution of each arm can be separated.
Storage & Handling
- Store the sealed lyophilised vial at −20°C, desiccated and protected from light.
- Reconstitute with bacteriostatic water, directing solvent down the vial wall — do not shake or vortex.
- Store reconstituted solution at 2–8°C and use within 7–14 days; aliquot and freeze at −20°C for longer storage.
- Avoid repeated freeze-thaw cycles, which degrade peptide integrity.
- Allow the vial to reach room temperature before opening to prevent condensation on the powder.
Reconstitution Calculator
Calculate dilution volumes for Retatrutide. For research reference only — always verify calculations independently.
Concentration vs Solvent Volume
The dashed line indicates your selected solvent volume. Lower solvent volume = higher concentration.
Research References
Related Research Articles
Frequently Asked Questions
What is Retatrutide?
Retatrutide is a novel triple-agonist peptide targeting GIP, GLP-1, and glucagon receptors simultaneously, studied in metabolic and energy expenditure research.
What sizes are available?
Retatrutide is available in 10mg and 30mg vials to accommodate different experimental scales and dosing protocols.
What is LY3437943?
LY3437943 is the development code for retatrutide. The two names refer to the same 39-amino-acid triple-agonist peptide, so published literature and supplier listings may use either.
Which receptors does Retatrutide act on?
Three: the GIP receptor (GIPR), the GLP-1 receptor (GLP-1R) and the glucagon receptor (GCGR). Reported potency is imbalanced, with the strongest activity at GIPR. The glucagon arm is what separates it from dual agonists such as tirzepatide.
How pure is your Retatrutide and how is it verified?
Every batch is analysed before release and the result is published on that batch's Certificate of Analysis, which is linked directly on this page. The CoA states the measured purity and identity data for the exact batch your vial is fulfilled from — we do not publish a single generic certificate across batches.
How should Retatrutide be stored?
Store the sealed lyophilised vial at −20°C, desiccated and protected from light. After reconstitution with bacteriostatic water, store at 2–8°C and use within 7–14 days, or aliquot and freeze at −20°C. Avoid repeated freeze-thaw cycles.
How do I reconstitute Retatrutide?
Direct bacteriostatic water slowly down the inside wall of the vial and allow the powder to dissolve without shaking or vortexing. The reconstitution calculator on this page converts your chosen solvent volume into concentration per unit.
Do you ship Retatrutide within the UK?
Yes — orders are dispatched from the UK with tracked delivery. Same-day dispatch applies to orders placed before the daily cut-off on working days.
Is Retatrutide legal to buy in the UK?
It is supplied and sold strictly as a laboratory research chemical for in-vitro use. It is not a licensed medicine and is not for human or veterinary use, consumption, or any therapeutic application.
Research-only — please read before ordering
Retatrutide is supplied strictly for in-vitro laboratory research. It is not approved for human or veterinary use. Our disclaimer explains permitted uses and prohibited applications.
Customer reviews
Reviews of the overall WG Peptides experience — ordering, service, dispatch, delivery and packaging — left by verified customers whose order included Retatrutide. They are not laboratory assessments of the compound.
- Verified order22 October 2026
Great experience
Fast delivery, excellent research peptide
Amy M.
- Verified order4 September 2026
Extremely pleasant experience for my first order.
I’ve researched products from many different websites across the internet in search for a reliable and trustworthy source and came across this website by pure chance after checking forums and reddit. I was quite novice in my knowledge of peptides and was hoping to find out a bit more before i commited to my first order. Every question i had was answered quickly and perfectly and in all honesty it was far above the level of any customer service i’ve experienced elsewhere. Not only was the ordering process and customer service easy and high quality, but so were the products. This was my first order on this website but since then i’ve returned time and again. Just wanted to share my experience, there’s not many businesses who are so transparent and helpful!
Ryan M.